Effectively wipe out 99.9% of the new coronavirus, new treatments may make the new coronavirus disappear completely
Effectively wipe out 99.9% of the new coronavirus, new treatments may make the new coronavirus disappear completely
Research teams in Australia and the United States have developed an experimental antiviral therapy that can reduce the amount of new coronavirus by 99.9%-gene-silencing RNA technology, which can improve the survival and mortality of infected mice.
Research teams in Australia and the United States have developed a new type of antiviral therapy-gene-silencing RNA (gene-silencing RNA) technology, which can wipe out 99.9% of the new coronavirus in mice.
Research teams in Australia and the United States have developed experimental antiviral treatments that can reduce the amount of new coronavirus by 99.9%. The team is currently conducting experiments on mice and proved that it can improve the survival rate and mortality of mice. In the surviving mice, the lungs have been acupuncture. No viruses can be detected.
Comprehensive Australian financial media "Business News Australia", Australian Broadcasting Corporation (ABC) reported, by the Australian Griffith University (Griffith University) affiliated Queensland Menzies Health Institute (Menzies Health Institute Queensland) and the American Beckman Institute ( A multinational team of researchers from the Beckman Research Institute published a new generation of antiviral therapy that can wipe out the new coronavirus in the international academic journal Molecular Therapy on May 13.
The research team used gene-silencing RNA (gene-silencing RNA) technology called small interfering RNA (siRNA) to directly attack the virus genome, making the virus unable to replicate. The team also customized lipid nanoparticles. The particles send small interfering ribonucleic acid directly into the patient’s lungs. The team has already conducted experiments on mice. Nigel McMillan, co-lead researcher who works at Griffith University, said, “The team injects lipid nanoparticles and they look for the virus by themselves, and then Destroy the virus like a heat-seeking missile."
He said that this is the first time they can send particles into blood vessels and attack viruses. Small interference ribonucleic acid is transported through blood vessels into the lungs and lung cells to destroy the lung cells infected by the virus. This therapy Reduced the amount of virus by 99.9%. He also emphasized that during the treatment process, normal cells would not be harmed at all.
Gene-silent RNA technology is mainly based on existing antiviral drugs such as Tamiflu and Remdesivir. The effects of these drugs are mainly to reduce the symptoms of the new crown and allow patients to recover earlier. However, McMillan pointed out, New technology can prevent the virus from replicating, so patients can recover on their own, and this method will also allow patients to recover faster.
McMillan pointed out that although the gene-silent RNA technology cannot completely "cure" patients with new crowns, its therapeutic effect is almost as good as a complete cure. In the mouse experiment, the team found that the surviving mice "have not detected anything in their lungs." "New Coronavirus", "Therapy has improved the survival rate and mortality of infected mice."
He said that this therapy can treat severely ill patients or mildly ill patients isolated in a quarantine center. For the former, vaccination is too late. For the latter, the therapy can ensure that patients will not suffer from the disease. If it’s fast enough, we can basically rule out people dying from this disease."
Anthony Fauci, Dean of the National Institute of Allergy and Infectious Diseases (NIAID), once pointed out that although a new crown vaccine is currently available on the market, there is still no direct treatment for the new crown virus. McMillan said that in terms of direct therapy , Gene silent RNA technology is considered the first.
Another advantage of gene-silent RNA technology is that it is not only suitable for fighting against the new coronavirus, it can also defeat variants of the new coronavirus, and even other types of coronaviruses. Research co-author Professor Kevin Morris of Griffith University said that this therapy is designed to deal with all subtypes of coronavirus, including SARS coronavirus (SARS-CoV-1), new coronavirus (SARS) -CoV-2), and any variant viruses developed in the future, he said that this technology mainly targets ultraconserved regions in the viral genome.
In addition, the nanoparticles used in the therapy can be stable for up to 12 months in an environment of 4 degrees Celsius, and generally can be maintained for more than one month at room temperature. Therefore, this method can also be used to treat patients with new crowns in a resource-poor environment. .
McMillan said that the team will conduct the next phase of clinical trials. If it goes well, it will be possible to perform this therapy on humans as early as 2023.
